Proofs and Refutations is essential reading for all those interested in the methodology, the philosophy and the history of mathematics. Much of the book takes the form of a discussion between a teacher and his students. They propose various solutions to some mathematical problems and investigate the strengths and weaknesses of these solutions. Their discussion raises some philosophical problems and some problems about the nature of mathematical discovery or creativity. Imre Lakatos is concerned throughout to combat the classical picture of (...) mathematical development as a steady accumulation of established truths. He shows that mathematics grows instead through a richer, more dramatic process of the successive improvement of creative hypotheses by attempts to 'prove' them and by criticism of these attempts: the logic of proofs and refutations. (shrink)

BackgroundAlthough patient advocates have developed templates for standard consent forms, evaluating patient preferences for first in human (FIH) and window of opportunity (Window) trial consent forms is critical due to their unique risks. FIH trials are the initial use of a novel compound in study participants. In contrast, Window trials give an investigational agent over a fixed duration to treatment naïve patients in the time between diagnosis and standard of care (SOC) surgery. Our goal was to determine the patient-preferred presentation (...) of important information in consent forms for these trials.MethodsThe study consisted of two phases: (1) analyses of oncology FIH and Window consents; (2) interviews of trial participants. FIH consent forms were analyzed for the location(s) of information stating that the study drug has not been tested in humans (FIH information); Window consents were analyzed for the location(s) of information stating the trial may delay SOC surgery (delay information). Participants were asked about their preferred placement of the information in their own trial’s consent form. The location of information in the consent forms was compared to the participants’ suggestions for placement. Results34 [17 FIH; 17 Window] of 42(81%) cancer patients approached participated. 25 consents [20 FIH; 5 Window] were analyzed. 19/20 FIH consent forms included FIH information, and 4/5 Window consent forms included delay information. 19/20(95%) FIH consent forms contained FIH information in the risks section 12/17(71%) patients preferred the same. Fourteen (82%) patients wanted FIH information in the purpose, but only 5(25%) consents mentioned it there. 9/17(53%) Window patients preferred delay information to be located early in the consent, before the “Risks” section. 3/5(60%) consents did this.ConclusionsDesigning consents that reflect patient preferences more accurately is essential for ethical informed consent; however, a one-size fits all approach will not accurately capture patient preferences. We found that preferences differed for FIH and Window trial consents, though for both, patients preferred key risk information early in the consent. Next steps include determining if FIH and Window consent templates improve understanding. (shrink)

This volume is a collection of essays by various contributors in honor of the late Laurence Berns, Richard Hammond Elliot Tutor Emeritus at St. John's College, Annapolis. The essays address the literary, political, theological, and philosophical themes of his life's work as a scholar, teacher, and constant companion of the "great books.".

Remembering the year of 1989 does not always seem to produce a coherent narrative about the recent history of Romania. Most likely, when asked about their own experiences or what truly happened back then, Romanians would refer to it as “the events” because there still is a certain veil of ambiguity over their shared collective memory. The author’s personal encounters with such story tellers confirm that Romanians are still torn apart between various interpretations concerning what happened during December 1989.

Ethics and Technology is a step-by-step, hands-on process that companies, civic organizations, and watchdog groups can use to assess the benefits - and costs - of technology. Featuring vignettes drawn from actual business cases, as well as sharply focused study questions, this resource offers tools for asking effective questions and making ethical decisions. John Hart's book will enable corporations, governments, communities, and individuals to get beyond competing ideologies to work cooperatively on a progressive reshaping of society.

In an attempt to combat the positivist view that the only legitimate way to conduct social science is in the manner of a natural science, Knight distinguished between positivist and non-positivist categories or levels of interpretation of human-social subject matter. Since each of the categories contained ‘a large element of truth’, Knight argued that any serious analysis would need to embrace a pluralist approach. In this paper I draw on four separate accounts he gave (in 1934, 1940, 1941, and 1942) (...) of these categories in order to arrive at a more complete statement. This fuller description will hopefully promote a deeper appreciation of Knight's emphasis on the need for adopting a pluralist approach to the subject matter of economics. I then apply the perspective of the categories to shed light on Knight's definition of economics and his criticism of Robbins' definition. (shrink)

People from Native American/First Nation spiritual traditions and from Christian religious backgrounds express sometimes contradictory, sometimes complementary perspectives on humans' role in an interrelated and interdependent "web of life." The extinction of salmon species in the Columbia-Snake river system of Canada and the United States, and the loss of salmon from the Haida Gwaii fisheries off the western coast of Canada, provide bioregional stimuli for reflection on whether nonhuman species have intrinsic value or solely instrumental value, and the extent to (...) which species preservation should have equitable status with, or take precedence over, human wants and apparent human needs. If societal needs and species conservation, and the common good of all creatures, are to be integrated for the good of the commons then a relational consciousness must replace "dominion" and "stewardship" attitudes toward creation. (shrink)

A renowned scholar charts the sprawling landscape of Door County, Wisconsin, explores the county's agricultural heritage and the difference between the Green Bay and Lake Michigan sides of the peninsula, and examines the cultural aspects of the region.

At one time, the American Medical Association had a strong pro-life position regarding unborn human beings. Using an online AMA archives database, this research note contrasts early AMA pro-life commentary with its eventual pro-choice position. Strong pro-life advocacy in the mid-to-late 1800s, led by doctors such as Horatio Storer, gave way in the 1900s to a waning of pro-life zeal, and eventually developed into a pro-choice stance on abortion.

This very ambitious and remarkably detailed book examines some of the most fundamental themes in Husserl's philosophy. As is evident from the title, the book has two parts, the first of which (pp. 1-101) discusses Husserl's methodology, esp. the phenomenological reduction, and the second of which (pp. 103-347) investigates the themes of space, time, and other. These themes are selected because they are central to our mundane and embodied experience of an objective, physical and animate world.

Confusion surrounds Catholic teaching on the use of assisted nutrition and hydration, specifically the question of when, if ever, its refusal or removal is ethical. This paper focuses on two often-neglected considerations: the relationship between means and mechanism, and an assessment of proportionality of the mechanism from the patient’s perspective. The authors draw on two critical principles of Catholic moral teaching: only ordinary means are required, and proportionality is subject to the perspective of the patient, not just that of experts (...) or the culture. The mechanisms that provide food and water have distinct benefits and burdens. Their proportionality is properly subject to analysis by the patient or surrogate, who determines which mechanism is acceptable in the patient’s situation. (shrink)

This book collects essays considering the full range of Robert Sokolowski's philosophical works: his vew of philosophy; his phenomenology of language and his account of the relation between language and being; his phenomenology of moral action; and his phenomenological theology of disclosure.

This festschrift collects a number of insightful essays by a group of accomplished Christian scholars, all of who have either worked with or studied under Hendrik Hart during his 35-year tenure as Senior Member in Systematic Philosophy at the Institute for Christian Studies, Toronto, Canada.

Thousands of youth suffering from acquired brain injury or other early-life neurological disease live, mature, and learn with only limited communication and interaction with their world. Such cognitively capable children are ideal candidates for brain-computer interfaces. While BCI systems are rapidly evolving, a fundamental gap exists between technological innovators and the patients and families who stand to benefit. Forays into translating BCI systems to children in recent years have revealed that kids can learn to operate simple BCI with proficiency akin (...) to adults. BCI could bring significant boons to the lives of many children with severe physical impairment, supporting their complex physical and social needs. However, children have been neglected in BCI research and a collaborative BCI research community is required to unite and push pediatric BCI development forward. To this end, the pediatric BCI Canada collaborative network was formed, under a unified goal to cooperatively drive forward pediatric BCI innovation and impact. This article reflects on the topics and discussions raised in the foundational BCI-CAN meeting held in Toronto, ON, Canada in November 2019 and suggests the next steps required to see BCI impact the lives of children with severe neurological disease and their families. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)